• A Tumorigenic Mll-Homeobox Network in Human Glioblastoma Stem Cells

    Cancer Research

    Glioblastoma growth is driven by cancer cells that have stem cell properties, but molecular determinants of their tumorigenic behaviour are poorly defined. In cancer, altered activity of the epigenetic modifiers Polycomb and Trithorax complexes may contribute to the neoplastic phenotype. Here, we provide the first mechanistic insights into the role of the Trithorax protein mixed-lineage leukemia (MLL) in maintaining cancer stem cell characteristics in human glioblastoma.