CSH Molecular Case Studies

Hi-C provides information on 3D genome conformation, but it can also be used to detect genetic structural variants. Here, we describe how we used Hi-C to detect structural variants of clinical significance in peripheral blood of pediatric leukemia patients.

Cancers

Review on the future of epigenetic therapies for glioblastoma. We specifically focus on epidrugs and other approaches that target epigenetic and chromatin factors in cancer stem cells. We also discuss some experimental challenges and the importance of appropriate patient-derived models for preclinical studies.

G3 Genes|Genomes|Genetics

Exploration of transcriptional process associated with hypoxia in Drosophila