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Gallo Laboratory

Research on brain cancer epigenomics

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EPIGENOMICS

Epigenomics studies the interplay between chromatin architecture and gene expression. Chromatin architecture, or the 3D genome, is the result of specific chemical modifications on the DNA and on proteins called histones. These changes are usually achieved by the effect of the modifications on DNA structure.

CANCER STEM CELLS

Cancer stem cells represent a population of cells in a tumor that have self-renewal properties. Experimental evidence has shown that in glioblastoma, cancer stem cells are therapy-resistant and constitute a reservoire for tumor recurrence.

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